Rejuran Healer is one of Korea’s most trusted regenerative treatments, beloved for its ability to repair damaged skin, smooth fine lines, shrink pores, and restore youthful radiance. As its popularity grows, especially among international visitors seeking Korean aesthetic treatments, questions about Rejuran Healer side effects naturally follow.
Although Rejuran is known for its exceptionally safe profile, it still involves intradermal injections, meaning temporary, visible reactions are completely normal. This guide breaks down which Rejuran side effects you can expect, what’s considered a red flag, how long symptoms last, and how to minimize downtime based on Korean dermatology standards.
If you’re comparing regenerative options, you may also want to explore our guides on exosome therapy, Korean skinboosters, or anti-aging skincare programs.
Understanding Normal Rejuran Healer Side Effects (0–72 Hours)
Rejuran delivers highly purified salmon DNA polynucleotides (PN) into the dermis to stimulate repair. Because injections are placed superficially, temporary bumps and inflammation are part of the process.
Redness & Flushing
Mild redness appears immediately after the procedure and usually fades within a few hours. This is simply the skin responding to micro-needling and the PN infusion.
Rejuran Injection Bumps (Papules)
The most common, and most misunderstood, side effect. Papules form because Rejuran is injected into the dermis rather than under it. These tiny raised bumps typically settle within 24–48 hours as the product spreads and absorbs.
Mild Swelling
Particularly noticeable around delicate areas such as the under-eyes. This swelling diminishes naturally as the PN binds to moisture.
Bruising
Small bruises may appear depending on your vascularity or whether you bruise easily. They fade within several days.
Tightness or Tingling
A sign that cellular repair is underway. Most patients describe this as a mild sensation lasting a few hours.
Less Common—but Still Normal—Reactions
Some patients may experience temporary welts, light hives (common in sensitive skin), or acne-like bumps if heavy makeup or occlusive skincare is applied too quickly after treatment. Redness lasting up to 72 hours is also normal as long as it steadily improves.
Rare Rejuran Healer Side Effects (When to Seek Help)
Although extremely uncommon, these are considered red flags:
Allergic Reaction
Symptoms may include itching, rashes, or heat. True allergies are rare because Rejuran is highly purified, but they should still be evaluated promptly.
Infection
Pain, heat, throbbing, intense swelling, or worsening redness 48–72 hours after treatment may indicate infection and require medical review.
Nodules
Hard lumps are rare but can form when injections are placed too superficially or if the skin reacts unevenly.
Jeunex physicians perform Rejuran with controlled depth and precision to avoid such risks.
How Skin Type Affects Rejuran Side Effects
Not all skin behaves the same. Here’s how different types typically respond:
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Fair skin: Redness appears stronger but fades quickly.
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Medium/olive tones: Slightly more swelling but moderate redness.
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Melanin-rich skin: No risk of hyperpigmentation from PN itself; any darkening usually comes from irritation caused by harsh post-care products.
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Sensitive skin: More prone to pinkness, hives, or extended tingling.
Rejuran vs Other Skinboosters: Side Effects Compared
Understanding how Rejuran differs from other injectables can help set expectations:
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Rejuran vs HA Skinboosters:
Rejuran produces more bumps, whereas HA skinboosters may cause Tyndall effect if placed too superficially. -
Rejuran vs Profhilo:
Profhilo spreads faster and produces fewer bumps, but tends to sting more. -
Rejuran vs Exosomes:
Exosomes have almost zero downtime. Rejuran has more visible temporary reactions but promotes deeper long-term repair.
How Long Do Rejuran Healer Side Effects Last?
Most reactions follow a simple timeline:
| Side Effect | Typical Duration |
|---|---|
| Redness | 1–24 hours |
| Papules/Bumps | 24–48 hours |
| Swelling | 12–48 hours |
| Bruising | 3–7 days |
Duration varies based on injection depth, skincare routine, hydration, skin sensitivity, and the treatment area.
How to Reduce Rejuran Downtime: Dermatologist-Approved Tips
Before Your Appointment
Avoid blood thinners, excessive alcohol, and stop retinoids 3–5 days before treatment.
After Treatment
Keep the skin cool, avoid saunas, workouts, and heat exposure for 24–48 hours. Stick to gentle hydration—nothing acidic, exfoliating, or oily. Avoid makeup for at least 24 hours.
Best Post-Treatment Products
Cica creams, panthenol balms, and barrier-repair moisturizers help soothe inflammation and speed recovery.
When Should You Contact a Clinic?
Contact your provider if you experience:
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Redness that worsens after 48–72 hours
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Increasing heat or throbbing
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Spreading swelling
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Hard nodules lasting more than 1–2 weeks
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Fever or flu-like symptoms
Jeunex offers dedicated post-care support for local and international patients.
Who Should Avoid Rejuran Healer?
Rejuran is not recommended for pregnant or breastfeeding individuals, those with active skin infections or open wounds, recent aggressive procedures, or severe autoimmune conditions.
Frequently Asked Questions
1. How long do Rejuran bumps last?
Usually 24–48 hours depending on injection depth and skin type.
2. Is Rejuran safe for darker skin tones?
Yes. Polynucleotides do not cause pigmentation, though irritation from harsh products may.
3. Does Rejuran have downtime?
Expect mild bumps and redness for 1–2 days.
4. How many sessions do I need?
Most patients undergo 3–4 treatments spaced 2–4 weeks apart.
5. Can I combine Rejuran with laser treatments?
Yes. Lasers are typically performed before Rejuran or after a 1–2 week interval.
Book Your Rejuran Healer Consultation at Jeunex Clinic
If you’re ready to repair your skin from within and restore long-lasting radiance, Jeunex Clinic in Seoul offers Rejuran Healer, Rejuran S, regenerative boosters, and customized combination treatments tailored to your skin goals.
Our dermatologists use precision micro-injection techniques and evidence-based Korean protocols to ensure optimal results with minimal downtime.
Schedule your personalized Rejuran Healer consultation at Jeunex Clinic today and experience Korea’s gold standard in regenerative skincare.
